One book series that has impressed me by being different, but remaining entertaining are Mike Mignola's take on the vampire myth. I will admit that I read the sequel first before I read the starting book to the series. I liked the classical feel that he used to tell the tale of a vampire hunter set during the early 20th century. Mignola's vamps are not just undead who drink blood, but are shape shifting ghouls who also feast on the flesh of the dead, and near dying. He describes them as carrion creatures.
I have also written a list of vampire books that I feel are worthy of being read found here - Best Vampire Books